Biaxin’s active ingredient is clarithromycin. It is also known by the generic name clarithromycin. Biaxin is commonly used to treat various bacterial infections, such as respiratory tract infections, skin infections, and stomach ulcers caused by certain bacteria.
Expect to pay anywhere from £1.94 to £4.29 for a pills of Biaxin. The disparity in cost arises from packaging volume and the grade of active ingredients (30 or 180 mg).
Biaxin contains clarithromycin as its active ingredient. Clarithromycin is a macrolide antibiotic that fights bacteria in the body. It is effective against a wide range of bacterial infections.
Biaxin is prescribed for various bacterial infections including, but not limited to, respiratory tract infections, skin infections, and Helicobacter pylori infections associated with duodenal ulcers. It is suitable for both adult and pediatric patients when used under proper medical supervision.
Biaxin is available in tablet form, extended-release tablets, and oral suspension. The standard dosage typically ranges from 250 mg to 500 mg taken twice daily, depending on the type and severity of the infection. Extended-release tablets are usually taken once daily. Pediatric dosages are calculated based on weight. Administration should follow the doctor’s prescription strictly.
Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacteria, thereby inhibiting the translocation steps in bacterial protein synthesis. Its bacteriostatic action effectively disrupts bacterial growth and replication.
After oral administration, clarithromycin is rapidly absorbed with peak plasma concentrations occurring within 2 to 3 hours. The bioavailability is approximately 50%. It undergoes extensive first-pass metabolism in the liver. The elimination half-life is around 3 to 4 hours for a 250 mg dose and 5 to 7 hours for a 500 mg dose. Excretion is primarily through the urine and feces.
Biaxin can interact with several other medications. Concomitant use with drugs like colchicine, lovastatin, and warfarin can lead to serious adverse effects. It is known to inhibit the cytochrome P450 3A (CYP3A) isoenzymes, thus affecting the metabolism of other drugs processed through this pathway.
Biaxin tablets should be stored at room temperature, away from excess heat and moisture. Oral suspension should be stored in a refrigerator and used within a specified period as mentioned on the labeling. Extended-release tablets must not be crushed or chewed and should be stored in their original packaging to protect from light and moisture.
Patients might experience side effects such as nausea, vomiting, taste changes, abdominal pain, and diarrhea. These side effects are generally mild and resolve once the treatment is discontinued. However, persistent or severe symptoms should be reported to a healthcare provider.
Serious adverse effects may include hepatotoxicity, QT prolongation leading to cardiac arrhythmias, severe allergic reactions, and pseudomembranous colitis. These require immediate medical attention.
Biaxin is contraindicated in patients with known hypersensitivity to clarithromycin, erythromycin, or other macrolide antibiotics. It is also contraindicated in patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior use of clarithromycin.
In pregnant women, Biaxin should be used only if clearly needed due to potential risk to the fetus. Caution is advised when prescribing to elderly patients due to the increased likelihood of decreased hepatic, renal, or cardiac function. Pediatric use should be carefully dosed based on the child’s weight and medical condition.
Signs of overdose may include gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Symptomatic treatment and supportive care should be provided immediately. Hemodialysis does not significantly remove clarithromycin from the body.
Regular monitoring of liver function tests is recommended during prolonged therapy. Electrocardiograms (ECGs) may be necessary for patients with existing heart conditions or those on potentially interacting drugs that prolong the QT interval.
Patients should be informed about the importance of taking the medication as prescribed, completing the full course of therapy to prevent resistance, and reporting any adverse effects to their healthcare provider promptly.
If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up. Continuity is crucial for effective treatment.