Cleocin is a medication whose active ingredient is clindamycin. It is also known by the name clindamycin phosphate. Cleocin is used to treat various bacterial infections, including those in the lungs, skin, blood, and reproductive organs. It helps stop the growth of bacteria in the body.
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The Cleocin price is approximately £1.64 – £2.48 per pills. It depends on the pack size and the amount of active ingredient (30 or 180 mg).
Cleocin, a brand name for clindamycin, is an antibiotic used to treat various bacterial infections. It belongs to the lincosamide class and works by inhibiting bacterial protein synthesis.
The active ingredient in Cleocin is clindamycin. It is available in different forms such as capsules, topical solutions, and injectables.
Cleocin is indicated for the treatment of serious infections caused by susceptible anaerobic bacteria and certain gram-positive bacteria. These include infections of the respiratory tract, skin and soft tissue, and infections of the abdomen.
Cleocin is available in multiple dosage forms, including 150 and 300 mg capsules, topical gel, vaginal cream, and injectable solutions. The choice of form depends on the type and severity of infection.
The typical adult dose ranges from 150 to 450 mg every six to eight hours depending on the severity of the infection. Pediatric doses are generally calculated based on body weight.
Clindamycin is absorbed quickly with an oral bioavailability of approximately 90%. It reaches peak plasma concentrations within one hour. It is metabolized in the liver and excreted in the bile and urine.
Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide chain elongation. This action is bacteriostatic but can be bactericidal in high concentrations or against highly susceptible organisms.
Bacterial resistance to clindamycin may occur through multiple mechanisms, such as modification of the ribosomal binding site, enzymatic inactivation, or efflux pumps. Resistance varies by geographic location and bacterial species.
Common adverse effects include gastrointestinal disturbances like nausea, vomiting, and diarrhea. Serious but rare effects include pseudomembranous colitis and severe skin reactions such as Stevens-Johnson syndrome.
Cleocin may interact with other drugs, including neuromuscular blocking agents and erythromycin. These interactions may alter the efficacy of clindamycin or increase the risk of adverse effects.
During prolonged therapy, periodic liver and kidney function tests, as well as blood counts, are recommended. This monitoring helps in detecting potential adverse effects early.
Cleocin should not be used in individuals with a history of hypersensitivity to clindamycin or lincomycin. It is also contraindicated in patients with a history of regional enteritis or ulcerative colitis when used in suppository form.
Dosage adjustments may be necessary for individuals with renal or hepatic impairment. In pregnant women, clindamycin should be used only if clearly needed, while caution is advised during lactation.
Cleocin should be taken with a full glass of water to minimize the risk of esophageal irritation. Topical forms should be applied thinly to the affected area, while the injectable form must be administered by healthcare professionals.
Store Cleocin capsules at room temperature away from moisture and heat. Topical forms should be stored in a cool, dry place, while injectable solutions must be kept as per manufacturer’s instructions, often requiring refrigeration.
Inform patients about the importance of completing the full course of therapy even if symptoms improve. Advise them to report any severe or persistent adverse effects to their healthcare provider promptly.