Lisinopril is a medication whose active ingredient is lisinopril. It is also known by brand names such as Zestril and Prinivil. Lisinopril is commonly used to treat high blood pressure and heart failure. It helps relax blood vessels, making it easier for the heart to pump blood.
The Lisinopril price is approximately £0.3 – £0.92 per pills. Depending on the size of the pack and the number of tablets inside (60 or 360 mg).
Lisinopril is an oral medication available in tablet form. Common dosages are 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, and 40 mg tablets.
The active ingredient in this medication is lisinopril. Each tablet’s strength indicates the amount of lisinopril present.
Lisinopril is classified as an angiotensin-converting enzyme (ACE) inhibitor. It works by inhibiting the conversion of angiotensin I to angiotensin II, reducing vasoconstriction.
Lisinopril blocks the conversion of angiotensin I to angiotensin II, leading to vasodilation and decreased aldosterone secretion. This reduces blood pressure and improves cardiac function.
Lisinopril is used primarily for treating hypertension, heart failure, and improving survival after myocardial infarction. It is also used in diabetic nephropathy management.
Lisinopril is taken once daily, with or without food. Consistent daily administration at the same time is recommended. Swallow tablet whole with water.
For hypertension, the initial dose is typically 10 mg once daily. For heart failure, the starting dose may be 5 mg once daily. Dosage adjustments are based on patient response and tolerability.
Dosage adjustments are made based on blood pressure response and renal function. Typically, increments occur at intervals of two to four weeks. Monitoring is essential.
The maximum recommended daily dose for hypertension is 40 mg. Doses above this do not generally increase efficacy and may increase the risk of side effects.
If a dose is missed, take it as soon as remembered. If it is close to the next dose, skip the missed dose. Do not double doses to make up for missed ones.
In case of overdose, symptomatic and supportive treatment is required. Intravenous infusion of saline solution may be necessary. Continuous monitoring of vital signs is essential.
Concurrent use of lisinopril with diuretics, NSAIDs, lithium, or potassium supplements can influence its effectiveness and increase risk of adverse effects. Monitoring levels and effects is important.
Patients with renal impairment may require lower initial dosages and cautious titration. Renal function should be closely monitored, especially in the initial stages of therapy.
While primarily excreted unchanged by the kidneys, patients with liver dysfunction may require careful monitoring, as altered metabolism can affect drug levels.
In elderly patients and those with severe kidney issues, cautious dosing and careful monitoring are advised. Pediatric usage is based on weight, and further specialized guidelines exist.
Common side effects include dizziness, headache, fatigue, and cough. These are generally mild and often resolve with continued use.
Serious side effects include hyperkalemia, hypotension, renal impairment, and angioedema. Immediate medical attention is required if serious side effects occur.
Contraindications include hypersensitivity to lisinopril or any ACE inhibitor, history of angioedema associated with prior ACE inhibitor therapy, and pregnancy.
Lisinopril is contraindicated in pregnancy due to the risk of harm to the fetus, including fetal renal impairment, oligohydramnios, and neonatal hypotension.
It is unknown if lisinopril is excreted in human milk. Caution is advised if administered to nursing women, considering potential risks and benefits.
Monitoring of blood pressure, renal function, and electrolytes is essential. Periodic blood tests are recommended to ensure patient safety and efficacy of treatment.
Store lisinopril at room temperature, between 20-25°C (68-77°F). Protect from moisture and light. Keep out of reach of children and pets.
Lisinopril should be dispensed in the original container to preserve integrity. Label the container with dosage and administration instructions clearly.
Dispose of unused or expired lisinopril according to local regulations. Do not flush medications down the toilet or pour them into a drain.
Patients should be counseled on the importance of adherence to prescribed dosage schedules, potential side effects, and the need for regular monitoring. Advise patients to report unusual symptoms.
The package includes a patient information leaflet. It is essential to review and provide the leaflet to patients, highlighting critical usage and safety information.
Lisinopril is a prescription-only medication. It is approved for use by healthcare professionals and subject to regulatory oversight to ensure safety and efficacy.