{"id":16,"date":"2025-08-02T20:42:27","date_gmt":"2025-08-02T20:42:27","guid":{"rendered":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/?post_type=product&p=16"},"modified":"2025-09-05T08:26:49","modified_gmt":"2025-09-05T08:26:49","slug":"danazol","status":"publish","type":"product","link":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/product\/danazol\/","title":{"rendered":"Danazol"},"content":{"rendered":"

General Information<\/h1>\n

\nDanazol is a synthetic androgen with antigonadotropic properties, used primarily for the treatment of endometriosis and fibrocystic breast disease. It works by inhibiting the release of gonadotropins from the pituitary gland, thus reducing ovarian activity and estrogen production.\n<\/p>\n

Mechanism of Action<\/h1>\n

\nDanazol exerts its effects through its interaction with androgen receptors, leading to decreased production of gonadotropins (LH and FSH) from the anterior pituitary. This suppression results in reduced ovarian hormone synthesis, mitigating symptoms related to endometriosis and fibrocystic breast disease.\n<\/p>\n

Pharmacokinetics<\/h1>\n

\nDanazol is well-absorbed orally, with peak plasma concentrations occurring approximately 2 to 8 hours post-administration. It has a half-life of 4.5 to 5.5 hours. Danazol is metabolized in the liver and primarily excreted as metabolites in the urine, with a minor percentage excreted in feces.\n<\/p>\n

Indications<\/h1>\n

\nIndicated for the treatment of moderate to severe endometriosis and fibrocystic breast disease. Additionally, Danazol may be used in patients with hereditary angioedema to prevent and treat attacks of angioedema.\n<\/p>\n

Dosage Information<\/h1>\n

\nFor endometriosis, the typical starting dose is 200\u00e2\u0080\u0093400 mg daily in divided doses. For fibrocystic breast disease, the usual dosage ranges from 100\u00e2\u0080\u0093400 mg daily. For hereditary angioedema, dosing must be individualized based on clinical response, typically between 200\u00e2\u0080\u0093600 mg daily.\n<\/p>\n

Administration Guidelines<\/h1>\n

\nDanazol should be taken orally with food to enhance its absorption. The dosage may be adjusted based on therapeutic response and tolerability, with routine monitoring of patient response to therapy.\n<\/p>\n

Contraindications<\/h1>\n

\nDanazol is contraindicated in patients with known hypersensitivity to the drug, active or history of thrombosis or thromboembolic disease, severe hepatic impairment, undiagnosed vaginal bleeding, pregnancy, and breastfeeding. It is also contraindicated in patients with porphyria.\n<\/p>\n

Drug Interactions<\/h1>\n

\nDanazol may interact with warfarin, increasing its anticoagulant<\/a> effect. Co-administration with statins may increase the risk of myopathy. Danazol can enhance the effects of cyclosporine and tacrolimus, requiring dose adjustments. Concurrent administration with carbamazepine and rifampin may reduce the efficacy of Danazol.\n<\/p>\n

Adverse Effects<\/h1>\n

\nCommon adverse effects include weight gain, acne, seborrhea, hirsutism, and voice changes. Serious side effects can include thromboembolic events, liver function abnormalities, and intracranial hypertension. Patients should be monitored for signs of adverse reactions throughout treatment.\n<\/p>\n

Monitoring Requirements<\/h1>\n

\nRegular liver function tests should be conducted to detect hepatotoxicity. Lipid profiles should be monitored, as Danazol can affect cholesterol and triglyceride levels. Periodic assessment of hematologic parameters is recommended, especially in long-term therapy cases.\n<\/p>\n

Special Populations<\/h1>\n

\nIn the elderly, dose adjustments may be required due to age-related hepatic and renal function impairments. Pediatric use is not recommended due to insufficient safety and efficacy data. In patients with renal impairment, caution and possible dosage adjustments are necessary.\n<\/p>\n

Storage Conditions<\/h1>\n

\nStore Danazol at room temperature, between 20\u00c2\u00b0C and 25\u00c2\u00b0C (68\u00c2\u00b0F to 77\u00c2\u00b0F). Keep the medication in a tightly sealed container, away from excessive heat, moisture, and light. Ensure that it is kept out of reach of children.\n<\/p>\n

Missed Dose Instructions<\/h1>\n

\nIf a dose is missed, the patient should take it as soon as they remember. If it is near the time of the next dose, they should skip the missed dose and resume their usual dosing schedule. Do not double the dose to catch up.\n<\/p>\n

Disposal Guidelines<\/h1>\n

\nUnneeded or expired Danazol should be disposed of properly. Do not dispose of medications in wastewater or household trash. Use drug take-back programs if available, or consult a pharmacist for appropriate disposal methods.\n<\/p>\n

Overdose Management<\/h1>\n

\nIn case of overdose, supportive care and symptomatic treatment should be provided. There is no specific antidote for Danazol overdose. Consideration should be given to the patient’s clinical status and the extent of overdose toxicity.<\/p>\n","protected":false},"excerpt":{"rendered":"

Danazol is a medication with the active ingredient danazol. It is also known by the brand names Danocrine and Danol. Danazol is used to treat endometriosis, fibrocystic breast disease, and to prevent attacks of hereditary angioedema.<\/p>\n

Danazol Price<\/h2>\n

The price spectrum for Danazol is set between \u00a31.2 and \u00a33.64 per pills. It’s mainly based on the pack’s volume and the strength of its active ingredients (30 or 180 mg).<\/p>\n","protected":false},"featured_media":46,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[16],"product_tag":[],"class_list":{"0":"post-16","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-womans-health","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-external"},"_links":{"self":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product\/16","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/comments?post=16"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/media\/46"}],"wp:attachment":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/media?parent=16"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_brand?post=16"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_cat?post=16"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_tag?post=16"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}