{"id":324,"date":"2025-08-23T06:51:34","date_gmt":"2025-08-23T06:51:34","guid":{"rendered":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/?post_type=product&p=324"},"modified":"2025-09-05T08:26:41","modified_gmt":"2025-09-05T08:26:41","slug":"aldactone","status":"publish","type":"product","link":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/product\/aldactone\/","title":{"rendered":"Aldactone"},"content":{"rendered":"

Medication Name<\/h1>\n

Aldactone (spironolactone) is an oral medication used to treat fluid retention (edema) in patients with conditions such as congestive heart failure, liver cirrhosis, and nephrotic syndrome. Additionally, it is prescribed for the management of high blood pressure and hyperaldosteronism.<\/p>\n

Chemical Composition<\/h2>\n

Aldactone contains spironolactone, a potassium-sparing<\/a> diuretic that functions by inhibiting aldosterone action in the distal renal tubules. Each tablet may contain 25 mg, 50 mg, or 100 mg of spironolactone as the active ingredient, along with inactive ingredients such as calcium sulfate, corn starch, croscarmellose sodium, magnesium stearate, and povidone.<\/p>\n

Pharmacodynamics<\/h3>\n

Spironolactone acts by antagonizing aldosterone receptors in the distal renal tubules, leading to increased excretion of sodium and water while conserving potassium. This mechanism decreases blood volume and, ultimately, blood pressure. Reduction in fluid retention also alleviates symptoms of edema in conditions like heart failure.<\/p>\n

After oral administration, spironolactone is rapidly absorbed and extensively metabolized in the liver to its active metabolites, including canrenone. Peak plasma concentrations of spironolactone occur within 3 to 5 hours. Its elimination half-life ranges from 1.3 to 2 hours, while canrenone exhibits a half-life of 13 to 24 hours. The drug is primarily excreted via urine and feces.<\/p>\n

Aldactone is indicated for the treatment of hypertension, edema associated with congestive heart failure, cirrhosis of the liver, and nephrotic syndrome. It is also used for diagnosing and treating primary hyperaldosteronism. Additionally, Aldactone can be used in the treatment of hypokalemia and as an adjunct in managing severe heart failure.<\/p>\n

Aldactone is typically administered orally, with optimal dosing individualized based on the specific condition being treated. It is recommended to take the medication with food to enhance absorption and reduce gastrointestinal discomfort. Regular administration times improve efficacy. Dosage adjustments are necessary for patients with renal impairment and elderly individuals.<\/p>\n

Dosage Recommendations<\/h2>\n

The initial dosage for hypertension treatment typically ranges from 25 mg to 100 mg daily, either in single or divided doses. In cases of edema, a daily dose of 25 mg to 200 mg is recommended. For diagnosing hyperaldosteronism, an initial dosage of 100 mg daily is common, potentially increasing to 400 mg if necessary. Always follow specific medical advice regarding dosage.<\/p>\n

Contraindications Overview<\/h3>\n

Aldactone is contraindicated in patients with hyperkalemia, Addison’s disease, anuria, or significant renal impairment. It should not be administered to patients with known hypersensitivity to spironolactone or any of its excipients. Concomitant use with eplerenone is also advised against due to the risk of hyperkalemia.<\/p>\n

Aldactone may interact with a variety of medications, including ACE inhibitors, angiotensin II receptor blockers, NSAIDs, digoxin<\/a>, and lithium, increasing the risk of hyperkalemia and other adverse effects. Concurrent use with potassium supplements or salt substitutes containing potassium can exacerbate potassium retention. Regular monitoring is required when Aldactone is used in combination with these drugs.<\/p>\n

Common adverse effects of Aldactone include hyperkalemia, hyponatremia, leg cramps, dizziness, gynecomastia, and gastrointestinal disturbances such as nausea and vomiting. Less common but severe effects may include blood dyscrasias, renal dysfunction, and severe allergic reactions. Patients should report immediate symptoms such as muscle weakness, palpitations, or confusion.<\/p>\n

Regular monitoring is crucial during Aldactone therapy. Blood pressure should be frequently assessed to evaluate the efficacy of hypertension treatment. Serum electrolytes, including potassium and sodium levels, must be monitored to detect and manage hyperkalemia or hyponatremia. Renal function tests are essential for patients with existing renal conditions or those at increased risk for renal impairment.<\/p>\n

Specific Patient Populations<\/h2>\n

Special considerations are required for different populations. In elderly patients, dosage adjustments may be necessary due to the increased risk of hyperkalemia and renal impairment. In pediatric patients, the safety and efficacy of Aldactone are not well established, necessitating cautious use. Pregnant and lactating women should avoid using Aldactone unless essential, due to potential risks to the fetus or breastfeeding infant.<\/p>\n

Therapeutic Efficacy Validation<\/h3>\n

A comprehensive evaluation of treatment efficacy includes assessing reductions in blood pressure, alleviation of edema symptoms, and normalization of serum potassium levels. Patient adherence to medication and lifestyle adjustments also significantly impact therapeutic outcomes. Regular follow-ups with healthcare providers are recommended to ensure ongoing efficacy and safety.<\/p>\n

Aldactone tablets should be stored at room temperature, away from moisture and heat sources. Keeping the medication in a tightly sealed container prevents degradation. It\u00e2\u0080\u0099s advisable to store Aldactone out of reach of children and pets to prevent accidental ingestion and potential adverse effects.<\/p>\n

Aldactone is a prescription-only medication and should be dispensed exclusively under the supervision of a healthcare professional. Patients must adhere strictly to prescribed dosages and follow medical advice to ensure the safe and effective use of the medication.<\/p>\n

Generic versions of spironolactone are widely available and offer a cost-effective alternative to Aldactone. These generics have the same active ingredient and comparable efficacy and safety profiles. A healthcare provider can offer guidance on the suitable use of either branded or generic options based on individual patient needs.<\/p>\n","protected":false},"excerpt":{"rendered":"

Aldactone, also known as Spironolactone, is a medication with the active ingredient spironolactone. It is used to treat conditions like high blood pressure, swelling due to heart failure, and low potassium levels. Aldactone helps reduce fluid retention and improves heart function.<\/p>\n

Aldactone Price Details<\/h2>\n

The general market rate for Aldactone varies from \u00a30.59 to \u00a31.01 per pills. Determining factors include the size of the packaging and the potency of its components (30 or 360 mg).<\/p>\n","protected":false},"featured_media":353,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[297],"product_tag":[],"class_list":{"0":"post-324","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-heart-disease","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-external"},"_links":{"self":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product\/324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/comments?post=324"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/media\/353"}],"wp:attachment":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/media?parent=324"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_brand?post=324"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_cat?post=324"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_tag?post=324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}