{"id":368,"date":"2025-08-14T15:53:06","date_gmt":"2025-08-14T15:53:06","guid":{"rendered":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/?post_type=product&p=368"},"modified":"2025-09-05T08:26:45","modified_gmt":"2025-09-05T08:26:45","slug":"hydrochlorothiazide","status":"publish","type":"product","link":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/product\/hydrochlorothiazide\/","title":{"rendered":"Hydrochlorothiazide"},"content":{"rendered":"

Medication Name<\/h1>\n

Hydrochlorothiazide<\/p>\n

Therapeutic Class<\/h2>\n

Thiazide Diuretic<\/a><\/p>\n

Primary Indications<\/h2>\n

Hypertension, Edema<\/p>\n

Mechanism Of Action<\/h2>\n

Hydrochlorothiazide inhibits sodium reabsorption in the distal tubules causing increased excretion of sodium and water, thereby reducing blood pressure.<\/p>\n

Dosage Forms<\/h2>\n

Tablets, Capsules<\/p>\n

Available Strengths<\/h2>\n

12.5 mg, 25 mg, 50 mg<\/p>\n

Administration Route<\/h2>\n

Oral<\/p>\n

Dosing Frequency<\/h2>\n

Once daily<\/p>\n

Maximum Dosage<\/h2>\n

100 mg per day<\/p>\n

Use In Combination<\/h2>\n

Often used with other antihypertensives like ACE inhibitors, beta-blockers, or ARBs.<\/p>\n

Drug-Drug Interactions<\/h2>\n

NSAIDs may reduce diuretic effectiveness. Lithium clearance is reduced, increasing toxicity risk. Concurrent use with corticosteroids can cause hypokalemia.<\/p>\n

Contraindications<\/h2>\n

Anuria, Hypersensitivity to Sulfonamide-Derived Drugs<\/p>\n

Precautionary Conditions<\/h2>\n

Severe Renal Impairment, Liver Disease<\/p>\n

Possible Side Effects<\/h2>\n

Hypokalemia, Hyperglycemia, Hyperuricemia, Photosensitivity<\/p>\n

Lab Monitoring<\/h2>\n

Serum Electrolytes, Renal Function, Blood Glucose<\/p>\n

Storage Conditions<\/h2>\n

Store at room temperature, protect from light and moisture.<\/p>\n

Overdose Management<\/h2>\n

Symptomatic and Supportive Treatment<\/p>\n

Non-Indicated Uses<\/h2>\n

Not indicated for initial treatment of malignant hypertension.<\/p>\n

Pediatric Use<\/h2>\n

Safety and Efficacy not established in children under 6 months.<\/p>\n

Geriatric Use<\/h2>\n

Monitor for hypokalemia and hypotension due to increased sensitivity.<\/p>\n

Pregnancy Category<\/h2>\n

Category B: Animal reproduction studies have not demonstrated risk.<\/p>\n

Lactation Considerations<\/h2>\n

Small amounts excreted in breast milk; use caution.<\/p>\n

Patient Counseling Information<\/h2>\n

Advise on the risk of photosensitivity, emphasizing the need to use sunscreen or wear protective clothing.<\/p>\n

Discontinuation Guidance<\/h2>\n

Do not abruptly discontinue without consulting a healthcare provider.<\/p>\n

Manufacturing Companies<\/h2>\n

Manufactured by various pharmaceutical companies such as Mylan, Sandoz, and Teva.<\/p>\n

Regulatory Status<\/h2>\n

FDA Approved<\/p>\n

Bioavailability<\/h2>\n

Intermediate<\/p>\n

Pharmacokinetics<\/h2>\n

Onset of action occurs in 2 hours, with peak effect at 4 to 6 hours. Half-life ranges between 6 to 15 hours.<\/p>\n

Effect On Mental State<\/h2>\n

No impact reported on mental alertness or coordination.<\/p>\n

Guideline Recommendations<\/h2>\n

Included in most guidelines as a first-line treatment for hypertension.<\/p>\n

Diabetes Considerations<\/h2>\n

May exacerbate hyperglycemic episodes in diabetic patients.<\/p>\n

Bone Density Effects<\/h2>\n

Long-term use may be associated with decreased bone mineral density.<\/p>\n

Fluid Retention<\/h2>\n

Effectively reduces fluid retention in conditions like congestive heart failure.<\/p>\n

Marketing Approval Date<\/h2>\n

First approved in 1959 for medical use.<\/p>\n

Alternative Names<\/h2>\n

HCTZ, Hydrodiuril, Esidrix<\/p>\n

Specific Populations<\/h2>\n

Adjust dosing in renal impairment, with careful monitoring for efficacy and toxicity.<\/p>\n

Cost Considerations<\/h2>\n

Generally inexpensive, often included in generic drug programs.<\/p>\n

Comorbidity Management<\/h2>\n

Useful in multifactorial therapeutic regimens targeting both hypertension and heart failure.<\/p>\n

Patient Adherence<\/h2>\n

Oral administration once daily enhances patient adherence.<\/p>\n

Alternative Therapies<\/h2>\n

Loop diuretics and potassium-sparing<\/a> diuretics can be considered based on clinical indications.<\/p>\n

Impact On Cholesterol<\/h2>\n

May cause a slight rise in cholesterol levels, requiring monitoring.<\/p>\n

Electrolyte Imbalances<\/h2>\n

Monitor closely for hyponatremia and hypokalemia during therapy.<\/p>\n

Dietary Considerations<\/h2>\n

Advise on maintaining a balanced diet rich in potassium sources to counteract hypokalemia.<\/p>\n

Physical Exercise<\/h2>\n

Encourage physical activity, but caution regarding potential dehydration and electrolyte imbalance.<\/p>\n

Long-Term Effectiveness<\/h2>\n

Remains effective for long-term management of hypertension and edema with appropriate monitoring.<\/p>\n

Renal Function<\/h2>\n

Periodic assessment of renal function is essential to avoid complications.<\/p>\n

Patient Education<\/h2>\n

Inform patients about the importance of adherence to therapy and regular follow-ups.<\/p>\n","protected":false},"excerpt":{"rendered":"

Hydrochlorothiazide is a medication with the active ingredient hydrochlorothiazide. It is also known by brand names like Microzide and HydroDiuril. This medication is mainly used to treat high blood pressure (hypertension) and can also help reduce swelling from fluid buildup in the body (edema).<\/p>\n

Hydrochlorothiazide Price<\/h2>\n

The cost of the Hydrochlorothiazide varies from \u00a30.23 to \u00a30.45 per pills. It depends on the pack size and the amount of active ingredient (60 or 360 mg).<\/p>\n","protected":false},"featured_media":398,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[296],"product_tag":[],"class_list":{"0":"post-368","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-blood-pressure","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-external"},"_links":{"self":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product\/368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/comments?post=368"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/media\/398"}],"wp:attachment":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/media?parent=368"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_brand?post=368"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_cat?post=368"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_tag?post=368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}