{"id":87,"date":"2025-08-24T06:40:41","date_gmt":"2025-08-24T06:40:41","guid":{"rendered":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/?post_type=product&p=87"},"modified":"2025-09-05T08:26:41","modified_gmt":"2025-09-05T08:26:41","slug":"hydrea","status":"publish","type":"product","link":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/product\/hydrea\/","title":{"rendered":"Hydrea"},"content":{"rendered":"

Medication Guide for Hydrea<\/p>\n

Active Ingredient Information<\/h2>\n

Hydrea contains hydroxyurea as the active ingredient. Hydroxyurea belongs to the class of medications known as antineoplastic agents. It inhibits DNA synthesis by blocking the enzyme ribonucleotide reductase.<\/p>\n

Indications for Use<\/h2>\n

Hydrea is primarily prescribed for the treatment of chronic myelogenous leukemia (CML), melanoma, and recurrent, metastatic, or inoperable ovarian cancer. It is also indicative for patients with resistant chronic phase or accelerated phase CML. Additionally, Hydrea can be used in sickle cell anemia to reduce the frequency of painful crises and the need for blood transfusions.<\/p>\n

Dosage Instructions<\/h2>\n

The dosage of Hydrea varies based on the condition being treated. For CML, the usual starting dose is 35 mg\/kg\/day. In melanoma and ovarian cancer, typical dosages range from 80 mg\/kg administered every third day to 80 mg\/kg per week. The specific dosing regimen should be prescribed by a healthcare professional based on individual patient needs.<\/p>\n

Administration Method<\/h2>\n

Hydrea is administered orally in the form of capsules. Patients are advised to swallow capsules whole with a glass of water. Do not crush or chew the capsules. Patients should adhere to their prescribed dosing schedule and consult their healthcare provider for any adjustments.<\/p>\n

Pharmacokinetics<\/h2>\n

Hydroxyurea is rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations occur within 1 to 4 hours after oral administration. The drug is distributed throughout bodily tissues and crosses the blood-brain barrier. It is primarily metabolized in the liver and excreted through the kidneys.<\/p>\n

Drug Interactions<\/h2>\n

Hydrea can interact with several other medications. Notable interactions include an increased risk of bleeding with anticoagulants like warfarin<\/a>, potentiated myelosuppressive effects when combined with other chemotherapeutic agents, and possible interference with antiretroviral drugs in HIV therapy. Patients must inform their healthcare provider of all medications they are currently taking.<\/p>\n

Side Effects<\/h2>\n

Common side effects of Hydrea include bone marrow suppression, nausea, vomiting, and diarrhea. Patients may also experience mucocutaneous changes such as skin ulcers, pigmentation changes, and erythema. Rare but severe side effects include pulmonary fibrosis, secondary leukemia, and severe myelosuppression.<\/p>\n

Contraindications<\/h2>\n

Hydrea is contraindicated in patients with significant bone marrow suppression, severe anemia, and hypersensitivity to hydroxyurea or any of its components. It should not be used in pregnant or lactating women unless absolutely necessary due to potential teratogenic effects.<\/p>\n

Monitoring Requirements<\/h2>\n

Patients on Hydrea require regular monitoring, including complete blood counts (CBC) every two weeks, renal and liver function tests, and physical examinations for potential skin abnormalities. Adjustments in dosage may be necessary based on the results of periodic monitoring. Healthcare providers should be vigilant in assessing any signs of toxicity.<\/p>\n

Storage Information<\/h2>\n

Hydrea capsules should be stored at room temperature, between 20\u00c2\u00b0C to 25\u00c2\u00b0C (68\u00c2\u00b0F to 77\u00c2\u00b0F), in a tightly closed container. Protect the medication from moisture and light. Keep it out of reach of children and pets to prevent accidental ingestion.<\/p>\n

Handling Instructions<\/h2>\n

Proper handling of Hydrea is crucial due to its cytotoxic nature. Caregivers should wear gloves when handling the capsules. In case of accidental contact, thoroughly wash the affected skin area or mucous membrane with soap and water. Do not open or disperse the capsule contents.<\/p>\n

Patient Counseling<\/h2>\n

Patients should be counseled on the importance of adhering to the prescribed dosing schedule, potential side effects, and the necessity for regular monitoring. Educate them about the signs of potential adverse effects such as unusual bleeding or bruising, persistent infections, and difficulty breathing.<\/p>\n

Clinical Efficacy<\/h2>\n

Clinical studies have demonstrated the efficacy of Hydrea in managing CML, with a significant increase in survival rates and reduction in symptoms. The drug has also shown promise in reducing the frequency of sickle cell crises and enhancing the overall quality of life in affected patients.<\/p>\n

Special Populations<\/h2>\n

Hydrea requires careful consideration in elderly patients, patients with renal or hepatic impairment, and those with a history of multiple cytotoxic treatments. Dose adjustments may be necessary to mitigate heightened risks of side effects and ensure therapeutic efficacy.<\/p>\n

Report Adverse Reactions<\/h2>\n

Healthcare professionals are encouraged to report any adverse reactions observed to the appropriate medical authorities or pharmacovigilance centers. Timely reporting can help in understanding the drug’s safety profile and in improving patient care outcomes.<\/p>\n

Pharmaceutical Form<\/h2>\n

Hydrea is available as oral capsules in 500 mg strength. These capsules are distinctly marked and should be handled following the provided instructions to ensure patient safety and medication integrity.<\/p>\n<\/h1>\n","protected":false},"excerpt":{"rendered":"

Hydrea contains the active ingredient hydroxyurea. It is also known as Droxia and Hydrea. This medication is used to treat certain types of cancer, like chronic myeloid leukemia, and a blood disorder called sickle cell anemia. It works by slowing or stopping the growth of cancer cells.<\/p>\n

Hydrea Price Information<\/h2>\n

The fiscal range for Hydrea stands at \u00a31.23 to \u00a31.73 per pills. The crux of the pricing revolves around pack dimensions and ingredient quality (30 or 360 mg).<\/p>\n","protected":false},"featured_media":115,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[151],"product_tag":[],"class_list":{"0":"post-87","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-other","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-external"},"_links":{"self":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product\/87","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/comments?post=87"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/media\/115"}],"wp:attachment":[{"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/media?parent=87"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_brand?post=87"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_cat?post=87"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.hamptonhealthpharmacy.co.uk\/online\/wp-json\/wp\/v2\/product_tag?post=87"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}