Motilium, also known by its active ingredient domperidone, is sometimes called Domstal or Costi. It is used to relieve nausea and vomiting, and can also help with feelings of bloating and fullness. This medication works by helping the stomach to move food more easily.
A pack of Motilium can cost anywhere between £0.22 and £0.29. The exact price depends on pack measurements and active ingredient density (90 or 360 mg).
Motilium contains the active ingredient domperidone, which is classified as a dopamine antagonist. This ingredient is primarily utilized to facilitate gastrointestinal motility and to alleviate symptoms of nausea and vomiting.
Domperidone works by blocking dopamine receptors located in the gastro-intestinal tract and the chemoreceptor trigger zone (CTZ). This inhibition enhances peristalsis and gastric motility, expediting gastric emptying and minimizing nausea.
Motilium is commonly indicated for conditions such as gastro-esophageal reflux disease (GERD), functional dyspepsia, and gastroparesis. It is also prescribed to relieve nausea and vomiting associated with various medical conditions, including chemotherapy and surgical procedures.
Typically, Motilium is administered at a dosage of 10 mg taken 3 times a day before meals. It is crucial to follow physician instructions regarding dosing schedules, and not to exceed the recommended dosage to avoid adverse effects. Variation in dose may be required based on severity of symptoms and patient response.
Following oral administration, domperidone is rapidly absorbed, with peak plasma concentrations reached in approximately 30-60 minutes. It undergoes extensive hepatic metabolism. The elimination half-life of domperidone is typically 7-9 hours, prolonged in patients with hepatic impairment.
Motilium may interact with various other medications, such as ketoconazole, erythromycin, and ritonavir, leading to increased risk of adverse effects. Concomitant use with antacids or antisecretory agents may impact the bioavailability of domperidone, requiring adjustment in dosage.
Motilium is contraindicated in patients with known hypersensitivity to domperidone or any of the excipients. It should not be used in individuals with prolactin-releasing pituitary tumors (prolactinoma), or with significant underlying cardiac conditions including prolonged QTc interval.
The use of Motilium during pregnancy should be considered only if the potential benefit justifies the potential risk to the fetus. Domperidone is excreted in breast milk in small amounts; therefore, caution is advised if administered to nursing mothers.
Common adverse effects of Motilium include dry mouth, abdominal cramps, and headache. Less frequently, it may cause breast tenderness or galactorrhea. Serious side effects can include cardiac arrhythmias, specifically QTc prolongation, and should prompt immediate medical attention.
In elderly patients, caution is advised due to an increased risk of adverse cardiovascular effects. Dosage adjustments may be necessary based on renal and hepatic function assessments. Pediatric use should be closely monitored under professional guidance.
Motilium should be stored at room temperature, between 15°C to 30°C, away from direct sunlight and moisture. Ensure the medication is kept out of reach of children and pets to prevent accidental ingestion.
If a dose of Motilium is missed, it should be taken as soon as remembered unless it is almost time for the next scheduled dose. Do not double up on doses to compensate for the missed one. Maintaining a consistent dosing schedule is essential for effective management of symptoms.
Motilium should not be abruptly discontinued without consulting a healthcare provider, particularly if used for chronic conditions. Gradual dose reduction may be necessary to mitigate withdrawal symptoms and to ensure stable symptom management.