Naltrexone is a medicine with the active ingredient Naltrexone hydrochloride. It is also known by other names like Revia and Vivitrol. This medication is used to help people stop taking drugs or drinking alcohol by blocking the effects these substances have on the brain.
The cost of the Naltrexone varies from £5.41 to £7.12 per pills. It depends on the size of the pack and the amount of active ingredient (10 or 90 mg).
Naltrexone
Naltrexone hydrochloride.
Opioid antagonist.
Typically available as tablets or injectable solution.
Treatment of alcohol dependence and opioid dependence.
Blocks opioid receptors in the brain, reducing the effects of alcohol and opioids.
Available in oral tablets and injectable formulations.
For alcohol dependence: 50 mg orally per day. For opioid dependence: 380 mg intramuscularly once a month.
Oral tablets should be taken with water. The injectable form must be administered by a healthcare provider.
Oral bioavailability approximately 5-40%. Peak plasma levels in about 1 hour post-oral ingestion.
Mainly metabolized in the liver to 6-beta-naltrexol.
Primarily excreted in urine, with some excretion in bile.
Patients should be opioid-free for 7-10 days before starting naltrexone therapy to avoid withdrawal symptoms.
May interact with medications that affect the liver, opioid analgesics, and certain psychiatric medications.
Contraindicated in patients currently on opioid analgesics, with acute hepatitis, or severe liver failure.
May include nausea, headaches, dizziness, fatigue, and anxiety.
Rare but may include liver damage, depression, and allergic reactions.
Liver function tests before and during treatment. Psychological evaluation to monitor for depression.
Adjustments may be necessary based on liver function and patient response. Consult with healthcare provider.
If a dose is missed, take it as soon as remembered unless it is close to the time for the next dose.
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Contact emergency services immediately. Symptoms may include severe nausea and vomiting.
Not recommended during pregnancy or breastfeeding unless the benefits outweigh the risks. Consult healthcare provider.
Inform patients about the potential for liver damage and the importance of regular liver function tests.
Varies depending on individual patient needs and response. Long-term therapy may be necessary.
Ensure the correct form of medication is provided (tablet or injectable). Verify dosage instructions with patient.
Some pharmaceutical companies offer financial assistance programs to help cover the cost of naltrexone.
Alternative medications for alcohol and opioid dependence include acamprosate, methadone, and buprenorphine.
Close collaboration with prescribing physician is essential to ensure safe and effective use.
Classified as a non-controlled substance but may be subject to prescription regulations.
Clinical studies indicate efficacy in reducing alcohol and opioid consumption when used as part of a comprehensive treatment program.
Educate patients about the importance of adherence to treatment and the potential consequences of missing doses.
Most insurance plans cover naltrexone, but prior authorization may be required.
Studies show naltrexone is effective but may be less effective than some opioid agonist therapies for opioid dependence.
Not commonly associated with withdrawal symptoms but may precipitate withdrawal in those currently using opioids.