Periactin is a medication whose active ingredient is cyproheptadine. It is also known by alternative names like Ciplactin and Peritol. This medication is used to treat allergy symptoms, such as itching, runny nose, and sneezing. It can also help stimulate appetite.
The cost of the Periactin varies from £0.36 to £0.49 per pills. It depends on the pack size and the amount of active ingredient (60 or 360 mg).
Periactin, known generically as Cyproheptadine, is an antihistamine used for treating allergy symptoms. It specifically works by blocking the action of histamine in the body.
Periactin is primarily indicated for allergic reactions such as hay fever, food allergies, and allergic skin conditions. Additionally, it may be used to manage symptoms of vascular headache and as an appetite stimulant.
Periactin inhibits the action of histamine at H1 receptors, mitigating allergic symptoms. It also exerts antiserotonergic effects, which can help in conditions like vascular headaches by counteracting serotonin-induced vascular changes.
Periactin is available in both tablet and syrup form. Tablets are commonly administered in 4 mg doses, whereas the syrup provides 2 mg of Cyproheptadine per 5 mL. The specific dosage form chosen depends on patient preference and clinical circumstances.
General dosing for adults starts at 4 mg taken 2-3 times daily. Pediatric dosing is often weight-based, initiated at lower doses such as 2 mg two to three times a day. The maintenance dose is adjusted depending on therapeutic response and tolerability.
Tablets should be taken orally with a glass of water. The syrup form should be measured accurately using a dosing spoon or cup. It is preferable to take Periactin with food to minimize potential gastrointestinal discomfort.
Common side effects include drowsiness, dizziness, and dry mouth. Gastrointestinal disturbances such as nausea and vomiting can also occur. Less frequently, Periactin can cause blurred vision or confusion, especially in older adults.
Periactin may interact with other central nervous system depressants, increasing their sedative effects. Concurrent use with monoamine oxidase inhibitors (MAOIs) is not advised due to potential exacerbation of antihistaminic side effects.
When administering Periactin, monitor for therapeutic effectiveness and side effects. Weight gain should be monitored if used as an appetite stimulant. Periodic assessment of liver function tests and complete blood counts may be warranted in prolonged use.
Cyproheptadine is well absorbed from the gastrointestinal tract. Peak plasma concentrations typically occur within 1 to 3 hours post-administration. The drug is metabolized in the liver and excreted via the urine.
Periactin should be used with caution in elderly patients due to increased susceptibility to anticholinergic effects. In pediatric populations, careful dose adjustments based on clinical response are crucial. It should be cautiously administered in patients with a history of asthma or other chronic respiratory disease.
Periactin is contraindicated in patients with known hypersensitivity to Cyproheptadine. It should not be used in newborns or premature infants. Contraindicated in patients with narrow-angle glaucoma, peptic ulcer, or urinary retention due to its anticholinergic properties.
Store Periactin at room temperature, away from direct sunlight and moisture. Keep the medication out of reach of children to prevent accidental ingestion.
In case of overdose, symptoms may include extreme drowsiness, hallucinations, or seizures. Immediate medical attention is necessary. Supportive treatment should be initiated, including gastric lavage and administration of activated charcoal if recently ingested.
Patients should be informed about the potential sedative effects and advised against operating heavy machinery or driving. Emphasize the importance of adhering to the prescribed dosage and not exceeding it. Patients should be educated on recognizing signs of adverse reactions and promptly reporting them to their healthcare provider.